7.77 Nucleic Acids, Structure, Function, Evolution and Their Interactions with Proteins


Class Info

Surveys primary literature, focusing on biochemical, biophysical, genetic, and combinatorial approaches for understanding nucleic acids. Topics include the general properties, functions, and structural motifs of DNA and RNA; RNAs as catalysts and as regulators of gene expression; RNA editing and surveillance, and the interaction of nucleic acids with proteins, such as zinc-finger proteins, modification enzymes, aminoacyl-tRNA synthetases and other proteins of the translational machinery. Includes some lectures but is mostly analysis and discussion of current literature in the context of student presentations.

This class has 7.05, and 7.51 as prerequisites.

7.77 will be offered this semester (Spring 2019). It is instructed by D. Bartel and U. RajBhandary.

Lecture occurs 3:00 PM to 6:00 PM on Wednesdays in 68-121.

This class counts for a total of 12 credits.

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