7.10[J] Physical Chemistry of Biomolecular Systems

Class Info

Provides a quantitative approach to understanding the physical and chemical laws that govern the behavior of biological macromolecules. Basic thermodynamics, state of a system, state variables. Work, heat, first, second, and third laws of thermodynamics. Entropy and its statistical basis, free energy representations, Legendre transforms, Maxwell relations, Gibbs function, Boltzmann distribution and partition functions. Equilibrium properties of macroscopic and microscopic systems; macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding, cooperativity, solvation, and titration of macromolecules. Meets with 5.60 first half of term.

This class has no prerequisites.

7.10[J] will not be offered this semester. It will be instructed by A. Jasanoff, C. Voigt and E. Alm.

This class counts for a total of 12 credits.

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