5.362 Kinetics of Enzyme Inhibition
Students study the activity and structure of the domains developed in 5.361 to understand the role of mutations in the development of resistance to Gleevec. Students assay both mutant and wild-type Abl kinase domains for phosphorylation activity to determine enzyme kinetics and the inhibition efficacy of Gleevec. They conduct additional testing on kinase activity of Gleevec-resistant mutants in the presence of other potential inhibitors. Uses structure-viewing programs to enable analysis of the mechanistic basis of Bcr-Abl inhibition and Gleevec-resistance.
5.362 will not be offered this semester. It will be available in the Spring semester, and will be instructed by B. Pentelute.
This class counts for a total of 5 credits. This class counts as a CI-M.
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