5.362 Kinetics of Enzyme Inhibition (New)


Class Info

Students study the activity and structure of the domains developed in 5.361 to understand the role of mutations in the development of resistance to Gleevec. Students assay both mutant and wild-type Abl kinase domains for phosphorylation activity to determine enzyme kinetics and the inhibition efficacy of Gleevec. They conduct additional testing on kinase activity of Gleevec-resistant mutants in the presence of other potential inhibitors. Uses structure-viewing programs to enable analysis of the mechanistic basis of Bcr-Abl inhibition and Gleevec-resistance.

This class has 5.07, 7.05, 5.352, 5.310, and 5.361 as prerequisites.

5.362 will not be offered this semester. It will be instructed by B. Pentelute.

This class counts for a total of 5 credits.

You can find more information at the http://www.google.com/search?&q=MIT+%2B+5.362&btnG=Google+Search&inurl=https site.

MIT 5.362 Kinetics of Enzyme Inhibition (New) Related Textbooks
MIT 5.362 Kinetics of Enzyme Inhibition (New) On The Web

© Copyright 2015