5.353 Macromolecular Prodrugs

Class Info

Students carry out an experiment that builds skills in how to rationally design macromolecules for drug delivery based on fundamental principles of physical organic chemistry. Begins with conjugation of a drug molecule to a polymerizable group through a cleavable linker to generate a prodrug monomer. Continues with polymerization of monomer to produce macromolecular (i.e., polymer) prodrug; monomer and polymer prodrugs are fully characterized. Rate of drug release is measured and correlated to the size of the macromolecule as well as the structure of the cleavable linker. Satisfies 4 units of Institute Laboratory credit.

This class has 5.352 as a prerequisite.

5.353 will be offered this semester (Spring 2019). It is instructed by J. Johnson and C. Rotsides.

Lecture occurs 9:00 AM to 10:00 AM on Tuesdays and Thursdays in 4-153.

This class counts for a total of 4 credits.

You can find more information at the MIT + 5.353 - Google Search site or on the 5.353 Stellar site.

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