20.475 Applied Developmental Biology and Tissue Engineering


Class Info

This subject addresses the integration of engineering and biology design principles to create human tissues and organs for regenerative medicine to drug development. Overview of embryogenesis; how morphogenic phenomena are governed by biochemical and biophysical cues. Analysis of in vitro generation of human brain, gut, and other organoids from stem cells. Roles of biomaterials and microreactors in improving organoid formation and function. Organoid use in modeling disease and physiology in vitro. Engineering and biological principles of reconstructing tissues and organs from postnatal donor cells using biomaterials scaffolds and bioreactors. Select applications such as liver disease, brain disorders, and others. Graduate students will have additional assignments.

This class has no prerequisites.

20.475 will not be offered this semester. It will be available in the Spring semester, and will be instructed by L. Griffith.

Lecture occurs 10:00 AM to 11:00 AM on Mondays, Wednesdays and Fridays in 16-220.

This class counts for a total of 12 credits.

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